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Press release from Australia:
"Key biological pathway reveals insights into #longCOVID brain fog"
"The identification of a metabolic pathway could lead to answers & new treatments for those experiencing brain fog because of long COVID"
https://newsroom.unsw.edu.au/news/science-tech/key-biological-pathway-reveals-insights-long-covid-brain-fog
#PwLC #PostCovidSyndrome #postcovid #postcovid19 #LC #Covidlonghaulers #longhaulers #COVIDー19 #COVID19 #Covidlonghaulers @longcovid @covid @covid19
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"Scientists from the School of Psychology and Faculty of Medicine & Health found that of the study cohort of 128 people, those who had a prolonged activation of the kynurenine pathway were more likely to have mild cognitive deficits 12 months after developing COVID-19. They also found that these symptoms were less likely to improve over time."
@longcovid @covid @covid19 #LongCovid #PwLC #PostCovidSyndrome #postcovid #postcovid19 #LC #Covidlonghaulers #longhaulers #COVIDー19 #COVID19 #COVID
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“I think when patients go to the doctor's with brain fog, it may be dismissed as a psychological problem. Our study speaks to the contrary, that there is a real biological mechanism behind #longCOVID #brainfog A/Prof. Cysique says.
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"The cognitive dysfunctions experienced by those with #longCOVID manifest most often as a lack of mental focus or clarity, or mental fatigue that is unusual compared to one’s previous capacity, especially after a cognitively demanding task (for example reading complex instructions, participating in a meeting that demands high concentration level, watching a documentary on a topic that is new and complex)."
@longcovid @covid @covid19 #PwLC #PostCovidSyndrome #postcovid #postcovid19 #LC
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"This is associated with short-term memory problems, difficulty in multi-tasking or concentration over long periods of time.
As A/Prof. Cysique explains, the best descriptor of #brainfog would be a flu-like physical and mental fatigue lasting months, although with some fluctuations."
@longcovid @covid @covid19 #LongCovid #PwLC #PostCovidSyndrome #postcovid #postcovid19 #LC #Covidlonghaulers #longhaulers #COVIDー19 #COVID19 #COVID
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"A/Prof. Cysique and her team discovered that at two months, when the kynurenine pathway was the most activated, 60 per cent of those who showed mild cognitive deficits, such as in attention/concentration and speed processing, showed an abnormal activation of the kynurenine pathway – abnormal meaning above the known abnormal level in reference samples of the same age."
@longcovid @covid @covid19 #LongCovid #PwLC #PostCovidSyndrome #postcovid #postcovid19 #LC #COVIDー19 #COVID19 #COVID
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"Because the kynurenine pathway is pro-inflammatory, the entire body, including the brain, is flooded by inflammatory products over a prolonged period."
@longcovid @covid @covid19 #LongCovid #PwLC #PostCovidSyndrome #postcovid #postcovid19 #LC #Covidlonghaulers #longhaulers #COVIDー19 #COVID19 #COVID
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From paper:
“The pattern of activation of the KP was associated with poorer cognitive function, and greater likelihood of cognitive impairment over-time. Importantly, no other blood biomarkers, sex, or clinical factors (pre-existing mental health or mental health during the study period, olfaction, medical comorbidities, disease severity or respiratory function) were associated with cognition.”
@longcovid @covid @covid19 #LongCovid #PostCovid #pwlc #PostCovid19