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Tom Kindlon

New US research

An In-Depth Exploration of the Autoantibody Immune Profile in ME/CFS Using Novel Antigen Profiling Techniques

Free fulltext:
mdpi.com/1422-0067/26/6/2799

@mecfs

Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disorder characterized by serious physical and cognitive impairments. Recent research underscores the role of immune dysfunction, including the role of autoantibodies, in ME/CFS pathophysiology. Expanding on previous studies, we analyzed 7542 antibody–antigen interactions in ME/CFS patients using two advanced platforms: a 1134 autoantibody Luminex panel from Oncimmune and Augmenta Bioworks, along with Rapid Extracellular Antigen Profiling (REAP), a validated high-throughput method that measures autoantibody reactivity against 6183 extracellular human proteins and 225 human viral pathogen proteins. Unlike earlier reports, our analysis of 172 participants revealed no significant differences in autoantibody reactivities between ME/CFS patients and controls, including against GPCRs such as β-adrenergic receptors. However, subtle trends in autoantibody ratios between male and female ME/CFS subgroups, along with patterns of herpesvirus reactivation, suggest the need for broader and more detailed exploration. Keywords: ME/CFS; immunity; autoantibodies; antiviral antibodies; herpesvirus; GPCR; β-adrenergic receptors; muscarinic receptors
Mar 21, 2025, 12:48 AM·Public·Web
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Tom Kindlon

2/

"The major outcome of our analysis is the lack of significant differences in AAb levels between ME/CFS patients and controls"

"we found elevated reactivity against specific EBV and HSV1 surface antigens"


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